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pexeva paroxetine mesylate is an orally administered psychotropic drug with a chemical structure related to paroxetine hydrochloride paxil .

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in vitro radioligand binding studies indicate that paroxetine has little affinity for muscarinic, alpha 1 -, alpha 2 -, beta-adrenergic-, dopamine d 2 -, 5-ht 1 -, 5-ht 2 -, and histamine h 1 -receptors; antagonism of muscarinic, histaminergic, and alpha 1 -adrenergic receptors has been associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs.

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for example, paxil paroxetine is believed to be the ssri most likely to cause weight gain.

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for the ssri selection, four ssris that were approved in japan for the treatment of mdd eg, paroxetine, sertraline, escitalopram, and fluvoxamine as of july 2014 were included.
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